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M8386 Sigma-Aldrich

α,β-Methyleneadenosine 5′-diphosphate sodium salt

CD73 inhibitor

Synonym: AMP-CP

  • CAS Number 104835-70-3

  • Empirical Formula (Hill Notation) C11H17N5O9P2

  • Molecular Weight 425.23

  •  MDL number MFCD00070019

  •  PubChem Substance ID 24897249

  •  NACRES NA.51

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Properties

Related Categories Biochemicals and Reagents, Nucleosides, Nucleotides, Oligonucleotides, Nucleotide Analogs More...
Quality Level   200
assay   ≥98% (HPLC)
form   powder
solubility   water: 50 mg/mL, clear to slightly hazy, colorless
storage temp.   −20°C
SMILES string   [Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)CP(O)(O)=O)C(O)C3O
InChI   1S/C11H17N5O9P2.Na.H/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(25-11)1-24-27(22,23)4-26(19,20)21;;/h2-3,5,7-8,11,17-18H,1,4H2,(H,22,23)(H2,12,13,14)(H2,19,20,21);;
InChI key   HEBWZOPLDYDXPJ-UHFFFAOYSA-N

Description

Application

α,β-Methyleneadenosine 5′-diphosphate sodium salt has been used as an ectonucleotidase/CD73 inhibitor to characterize the mode of adenosine production and as an inhibitor for in vitro studies.

Packaging

10, 25 mg in poly bottle

5 mg in glass bottle

Biochem/physiol Actions

α, β-Methyleneadenosine 5′-diphosphate (AMP-CP) is an ADP analog that as an ability to inhibit ectonucleotidase/ CD73 inhibitor and is used to study adenosinergic signaling regulation via CD73/ecto-5′-nucleotidase.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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