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M8535 Sigma-Aldrich

D-Magainin II amide

≥97% (HPLC)

  • CAS Number 129696-25-9

  • Empirical Formula (Hill Notation) C114H181N31O28S

  • Molecular Weight 2465.91

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Properties

assay   ≥97% (HPLC)
composition   Peptide content, ~70%
storage temp.   −20°C
SMILES string   CC[C@@H](C)[C@@H](NC(=O)CN)C(=O)NCC(=O)N[C@H](CCCCN)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](Cc2c[nH]cn2)C(=O)N[C@H](CO)C(=O)N[C@H](C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](Cc3ccccc3)C(=O)NCC(=O)N[C@H](CCCCN)C(=O)N[C@H](C)C(=O)N[C@H](Cc4ccccc4)C(=O)N[C@H](C(C)C)C(=O)NCC(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CO)C(N)=O

Description

Application

The all-D maganin peptides were resistant to enzymatic degradation and caused equivalent amounts of electrical conductivity when tested in planar lipid bilayers. The D enantiomers were equally active against representative Gram-negative and Gram-positive species.

Biochem/physiol Actions

Antibiotic peptide. Thought to preferentially bind to anionic phospholipids abundant in bacterial membranes with the formation of dynamic peptide-lipid supramolecular pore and cell permeabilization, magainins are positively charged and amphiphatic. Binding to artificial neutral membranes has also been demonstrated.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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