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M9948 Sigma-Aldrich

Mirin

≥98% (HPLC), powder

Synonym: 5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one

  • CAS Number 299953-00-7

  • Empirical Formula (Hill Notation) C10H8N2O2S

  • Molecular Weight 220.25

  •  MDL number MFCD05885480

  •  PubChem Substance ID 329818100

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cell Stress,
InChI Key   YBHQCJILTOVLHD-YVMONPNESA-N
Quality Level   100
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   red to orange
solubility   DMSO: >10 mg/mL
storage temp.   2-8°C
Gene Information   human ... MRE11A(4361)

Description

Application

Mirin has been used:
• as a small molecule inhibitor of meiotic recombination 11 (MRE11), in the pre-treatment of HCT116 wildtype cells before irradiation
• as Mre11 inhibitior in BSC-1 cells infected with simian virus 40
• in the pre-treatment of W12E cells for quantification of human papilloma virus (HPV) episome levels and to potentiate the effect of polyamide-25 (PA-25)

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Mirin causes cell cycle arrest at G1 phase. Mirin sensitizes virus to antiviral polyamides (AVP). In human papilloma virus (HPV) episomes, mirin promotes damage by forming double stranded DNA breaks. It aids in reducing the inhibitory concentration (IC50s) of AVP.

Mirin is an inhibitor of the Mre11-Rad50-Nbs1 complex. It disrupts nuclease activity of Mre11 and thus, the ability to repair DNA double strand breaks.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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