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MAK237 Sigma-Aldrich

Beta-Secretase Activity Fluorometric Assay Kit

sufficient for 100 fluorometric tests

  •  NACRES NA.84

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Description

General description

β-Secretase has been implicated to be an excellent target for anti-amyloid therapy for the treatment of Alzheimer’s disease.

Suitability

Suitable for the determination of ß-Secretase activity in biological and purified samples.

Principle

The β-Secretase activity Assay Kit provides a convenient fluorescence method for detecting β-secretase activity in biological and purified samples. The assay utilizes a secretase-specific peptide conjugated to two reporter molecules EDANS and DABCYL. In the uncleaved form, the fluorescent emissions from EDANS are quenched by the physical proximity of the DABCYL moiety. Cleavage of the peptide by secretase physically separates EDANS and DABCYL allowing for the release of a fluorescent signal. The level of secretase enzymatic activity in samples is proportional to the level of fluorescence intensity.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
Protocols & Articles
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