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SILuCHOP Stable-Isotope Labeled CHO Proteins

CHO Host Cell Protein Mixture

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Properties

packaging   vial of 100 μg
suitability   suitable for
  suitable for mass spectrometry
shipped in   wet ice
storage temp.   −20°C

Description

General description

Contamination of final product with Host Cell Proteins (HCPs) is a major concern for the development and production of Biotherapeutics in CHO cell lines. SILuCHOP is a representative heavy-isotope labeled standard of secreted host cell proteins, thus facilitating identification of biotherapeutics with contaminant host cell proteins by mass spectrometry.

Legal Information

SILu is a trademark of Sigma-Aldrich Co. LLC

This product is licensed under U.S. Patent No. 7,396,688 and foreign counterparts from E. I. du Pont de Nemours and Company. The purchase of this product conveys to the buyer the nontransferable right to use the purchased amount of the product for research and development only, including services for a third party for consideration. The buyer cannot sell or otherwise transfer this product, its components or materials made using this product or its components to a third party. Information about licenses for excluded uses is available from: E. I. du Pont de Nemours and Company; Attn: Associate Director, Commercial Development; DuPont Experimental Station E268; 200 Powdermill Rd.; Wilmington, DE 19803; 1-877-881-9787 (voice), 1-302-695-1437 (fax), licensing@dupont.com.

Safety & Documentation

Safety Information

RIDADR 
UN 1824 8 / PGII
Protocols & Articles

Articles

Quantification of Host Cell Proteins in Biotherapeutics using Stable Isotope Labeled Chinese Hamster Ovary Proteins (SIL-CHOP) as an Internal Standard

Residual presence of host cell proteins (HCPs) in recombinant therapeutic products has considerable clinical safety risks associated with a potential immunological response in patients. Although trad...
Keywords: BCA assay, Cell culture, Clinical, Enzyme-linked immunosorbent assay, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Purification, Solid phase extractions

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