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N0915 Sigma-Aldrich

NSC43067

≥98% (HPLC)

Synonym: 1-(5-Methyl-2-thienyl)-3-phenyl-2-Propen-1-one, 1-(5-Methyl-thiophen-2-yl)-3-phenyl-propenone, NSC 43067

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cyclin-Dependent Kinase (CDK),
InChI Key   AOUMOFQEBZGSPD-CMDGGOBGSA-N
assay   ≥98% (HPLC)
form   powder
color   light yellow to light tan
solubility   DMSO: >20 mg/mL
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

NSC43067 is a Cyclin-dependent kinase (Cdk) inhibitor which binds to a novel conserved site on Cdk, presumably the p27 binding pocket. The binding apparently directly induces Cdk1, Cdk2, and Cdk4 protein aggregation. Cdks 1, 2, 4, and 6 are the key Cdks that regulate the cell cycle, and are a target for a cancer treatment. NSC43067 arrests the cell cycle at the G0/G1 phase at lower concentrations and at the G2/M cell cycle phase at higher concentrations. The action appears to be reversible.

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

CDKs

Cyclin dependent kinases (CDKs) are typical serine/threonine kinases that display the 11 subdomains shared by all kinases. The complete sequence of the Homo sapiens genome shows that among the ~30,00...
Keywords: Alzheimer Disease, Apoptosis, Atomic absorption spectroscopy, Cancer, Cardiovascular, Catalysis, DNA replication, Diseases, Gene expression, Parkinson Disease, Phosphorylations, Transcription

Peer-Reviewed Papers
15

References

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