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N1019 Sigma-Aldrich

(−)-Nicotine hemisulfate salt

≥95% (TLC), ~35 % (w/v) in H2O (based on free base)

Synonym: (−)-1-Methyl-2-(3-pyridyl)pyrrolidine

  • CAS Number 65-30-5

  • Linear Formula (C10H14N2)2 · H2SO4

  • Molecular Weight 422.54

  •  MDL number MFCD00148918

  •  PubChem Substance ID 24897454

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Properties

Related Categories Agonists, Alkaloid, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
InChI Key   IECQULMJVNSKDB-RCWTXCDDSA-N
assay   ≥95% (TLC)
concentration   ~35 % (w/v) in H2O (based on free base)
color   dark brown

Description

General description

Nicotine is found in the leaves of Nicotiana species. It binds to nicotinic acetylcholine receptors and inhibits endogenous neurotransmitters. Nicotine is associated with lung cancer development and reduces the efficiency of chemotherapeutic agents. It is used to treat Alzheimer′s and Parkinson′s disease.

Application

(−)-Nicotine hemisulfate salt has been used to study the influence of nicotine on the severity of choroidal neovascularization (CNV). It also has been used as a natural nectar alkaloid to study the effect of self-medication in bumblebees.

Packaging

25, 100 mL in glass bottle

Biochem/physiol Actions

Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.

Quality

Mixture of nicotine base and nicotine sulfate.

Caution

Shelf-life of the solution as supplied is at least six years when stored at room temperature.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 1658 6.1 / PGII
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Making Headway

Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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