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N1165 Sigma-Aldrich

Pimonidazole

≥98% (HPLC)

Synonym: NSC 380540, PD 126675;, Ro 03-8799;, alpha-((2-Nitroimidazol-1-yl)methyl)-1-piperidineethanol;, alpha-[(2-Nitro-1H-imidazol-1-yl)methyl]-1-piperidineethanol

  • CAS Number 70132-50-2

  • Empirical Formula (Hill Notation) C11H18N4O3

  • Molecular Weight 254.29

  •  MDL number MFCD00867974

  •  PubChem Substance ID 329818508

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cell Stress,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   yellow
solubility   DMSO: >20 mg/mL
storage temp.   2-8°C
SMILES string   OC(CN1CCCCC1)Cn2ccnc2[N+]([O-])=O
InChI   1S/C11H18N4O3/c16-10(8-13-5-2-1-3-6-13)9-14-7-4-12-11(14)15(17)18/h4,7,10,16H,1-3,5-6,8-9H2
InChI key   WVWOOAYQYLJEFD-UHFFFAOYSA-N

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Pimonidazole is an effective and nontoxic exogenous 2-nitroimidazole hypoxia marker. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids.

Pimonidazole possesses a nitro group at position 2 and an imidazole ring. Pimonidazole undergoes reduction and is activated in hypoxic cells.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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