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N1638 Sigma-Aldrich

Nystatin Suspension

suspension, 10,000 unit/mL in DPBS, aseptically processed, BioReagent, suitable for cell culture

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Properties

Related Categories Antibiotic Solutions, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Mechanism of Action,
Quality Level   200
sterility   aseptically processed
product line   BioReagent
form   suspension
concentration   10,000 unit/mL in DPBS
application(s)   cell culture | mammalian: suitable
impurities   endotoxin, tested
color   yellow
Mode of action   cell membrane | interferes
antibiotic activity spectrum   fungi
  yeast
shipped in   dry ice
storage temp.   −20°C
SMILES string   C[C@@H]1OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@]2(O)C[C@H](O)[C@H]([C@H](C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\CC\C=C\C=C\[C@H](C)[C@@H](O)[C@@H]1C)O2)C(O)=O
InChI   1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28+,29-,30+,31+,32+,33+,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
InChI key   VQOXZBDYSJBXMA-QEKUPDCNSA-N

Description

General description

Chemical structure: polyene

Application

Nystatin suspension has been used:
• to inhibit caveolin-mediated endocytosis
• as a component of Eagle′s minimum essential medium (EMEM)
•  to enumerate lactic acid bacteria (LAB)

Biochem/physiol Actions

Nystatin is a polyene, broad-spectrum antibiotic, which modifies the microstructure of lipid rafts. It can sequester cholesterol present on the cell membrane of eukaryotes. Nystatin regulates immune responses through cytokine signaling, lymphocyte activation and pathogen recognition.

Caution

This product is stable at 37°C for three days.

Preparation Note

This suspension consists of 10,000 units/mL Nystatin in Dulbecco′s Phosphate Buffered Saline. It is aseptically processed, sterility testeed by USP and cell culture tested.

Other Notes

20ml, 100ml

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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