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N170 Sigma-Aldrich

NS 1619

powder

Synonym: 1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one

  • CAS Number 153587-01-0

  • Empirical Formula (Hill Notation) C15H8F6N2O2

  • Molecular Weight 362.23

  •  MDL number MFCD00928190

  •  PubChem Substance ID 24277860

  •  NACRES NA.32

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Ion Channels, Monovalent Ion Channels, Potassium Channel Modulators,
form   powder
color   white
solubility   45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47 mg/mL
  ethanol: 26.6 mg/mL
  0.1 M NaOH: 5.2 mg/mL
  DMSO: 5.3 mg/mL
  H2O: insoluble
SMILES string   Oc1ccc(cc1N2C(=O)Nc3cc(ccc23)C(F)(F)F)C(F)(F)F
InChI   1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)
InChI key   YLFMCMWKHSDUCT-UHFFFAOYSA-N
Gene Information   mouse ... Kcnma1(16531)
rat ... Kcnma1(83731)

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

NS 1619 is a selective large conductance Ca2+-activated K+-channel activator. The compound is known for its vasodilating and anti-proliferative properties. It is studied that NS 1619 can protect cardiac muscle against ischemia and reperfusion injury.

NS-1619 can promote the formation of mitochondrial reactive oxygen species (ROS) in cardiac myocytes. It enhances the formation of ROS in cultured brain slices. NS-1619 has the ability to enhance HO-1 activity in wild-type (WT) animals.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Caution

Photosensitive

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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