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N2165 Sigma-Aldrich

NKY80

≥98% (HPLC)

Synonym: 2-Amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone

  • CAS Number 299442-43-6

  • Empirical Formula (Hill Notation) C12H11N3O2

  • Molecular Weight 229.23

  •  MDL number MFCD02026323

  •  PubChem Substance ID 329818599

  •  NACRES NA.77

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Properties

Related Categories Adenylyl Cyclase Inhibitors, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   SOJUSNIBPPMLCC-UHFFFAOYSA-N
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   off-white to light brown
solubility   DMSO: ≥30 mg/mL
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

NKY80 is a selective adenylyl cyclase-V inhibitor with greater than 200-fold selectivity for type V over the type II isoform.

Features and Benefits

This compound is a featured product for ADME Tox and Cyclic Nucleotide research. Discover more featured ADME Tox and Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Adenylyl cyclases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for ADME/Tox

A significant number of drugs that fail in clinical trials have been associated with safety issues, including unexpected drug-drug interactions (DDI) or lack of efficacy due to poor pharmacokinetics....
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Discover Bioactive Small Molecules for Cyclic Nucleotides

Transmission of an extracellular signal across the cell membrane is initiated by activation of many types of hormone and neurotransmitter receptors, such as G-protein coupled receptors (GPCRs), and c...
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Peer-Reviewed Papers
15

References

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