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N5023 Sigma-Aldrich

Nordihydroguaiaretic acid

≥90% (HPLC), from Larrea divaricata (creosote bush)

Synonym: 1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane, 4,4′-(2,3-Dimethyltetramethylene)dipyrocatechol, Masoprocol, NDGA

  • CAS Number 500-38-9

  • Linear Formula [-CH(CH3)CH2C6H3-1,2-(OH)2]2

  • Molecular Weight 302.36

  •  Beilstein/REAXYS Number 2056826

  •  EC Number 207-903-0

  •  MDL number MFCD00002206

  •  PubChem Substance ID 57654453

  •  NACRES NA.77

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Properties

Related Categories A to C, Application Index, Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
Quality Level   200
biological source   Larrea divaricata (creosote bush)
assay   ≥90% (HPLC)
form   crystalline
mp   184-186 °C (lit.)
solubility   ethanol: 50 mg/mL, clear to slightly hazy
SMILES string   CC(Cc1ccc(O)c(O)c1)C(C)Cc2ccc(O)c(O)c2
InChI   1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3
InChI key   HCZKYJDFEPMADG-UHFFFAOYSA-N
Gene Information   human ... ALOX15(246), PTGS1(5742), PTGS2(5743)
mouse ... Alox12(11684)

Description

Packaging

1 g in poly bottle

5 g in glass bottle

500 mg in poly bottle

Biochem/physiol Actions

Lipoxygenase inhibitor; polyphenol-bearing o-dihydroxy (catechol) structure.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
UX1750000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

HPLC Analysis of Antioxidants on SUPELCOSIL™ LC-18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Antioxidants on SUPELCOSIL™ LC-18
Keywords: Chromatography, Cosmetics, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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