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O0391 Sigma-Aldrich

Olopatadine hydrochloride

≥98% (HPLC)

Synonym: (11Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride, AL-4943A, KW-4679, Opatanol, Patanol

  • CAS Number 140462-76-6

  • Empirical Formula (Hill Notation) C21H23NO3·HCl

  • Molecular Weight 373.87

  •  MDL number MFCD00875716

  •  PubChem Substance ID 329818840

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, O
InChI Key   HVRLZEKDTUEKQH-NOILCQHBSA-N
assay   ≥98% (HPLC)
form   solid
solubility   H2O: ≥20 mg/mL
storage temp.   room temp

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Olopatadine is a histamine H1 receptor antagonist and mast cell stabilizer. The low level of occupancy H1 receptors in the brain explains the low sedation effect of olopatidine. It is believed that olopatidine is a substrate for P-glycoprotein, which limits its brain penetration.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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