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O8014 Sigma-Aldrich

Org 27569

≥98% (HPLC)

Synonym: 5-Chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-ylphenyl)ethyl]amide

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Properties

Related Categories Cannabinoids, Cell Biology, Cell Signaling and Neuroscience, Neurobiology, Neuroscience,
InChI Key   AHFZDNYNXFMRFQ-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
color   white
solubility   H2O: <2 mg/mL
  DMSO: >5 mg/mL
storage temp.   2-8°C

Description

Biochem/physiol Actions

Org 27569 is an allosteric modulator of CB1 cannabinoid receptor. It significantly increases the binding of CB1 receptor agonist [3H]-CP 55,940 (pKB = 5.67) and causes a significant decrease in specific binding of CB1 receptor inverse agonist SR141716A (Rimonabant; pKB = 5.95); in the reporter gene assay behaves as insurmountable CP 55,940 antagonist; pKB = 7.57 at CB1 receptors in mouse vas deferens

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Cannabinoid Receptors

Cannabinoid receptors derive their name from Δ9-tetrahydrocannabinol (Δ9-THC), the psychoactive principle in Cannabis sativa (marijuana). Although marijuana has been in use for over 4,000 years as a ...
Keywords: AGE, Atomic absorption spectroscopy, Endocannabinoids, Gene expression, Infrared spectroscopy, Ligands, Metabolism, Neurotransmitters, Transduction

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