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P0049 Sigma-Aldrich

Pyronaridine tetraphosphate

Synonym: 2-Methoxy-7-chloro-10[3′,5′-bis(pyrrolidinyl-1-methyl-)4′-hydroxyphenyl]aminobenzyl-(b)-1,5-naphthyridine tetraphosphate

  • CAS Number 76748-86-2

  • Empirical Formula (Hill Notation) C29H32ClN5O2·4H3PO4

  • Molecular Weight 910.03

  •  MDL number MFCD05863545

  •  PubChem Substance ID 329819999

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antiparasitic / Antiprotozoal / Anthelminthic, Biochemicals and Reagents,
InChI Key   YKUQEKXHQFYULM-UHFFFAOYSA-N
Mode of action   enzyme | interferes
antibiotic activity spectrum   parasites
storage temp.   2-8°C

Description

Application

Pyronaridine, an acridine derivative, is used in China as a treatment for drug-resistant falciparum malaria. It′s in vitro activities have been studied against Plasmodium falciparum in Cameroon.

Packaging

250 mg in glass bottle

Biochem/physiol Actions

Pyronaridine has antimalarial activity and is used in conjunction with artensunate. It is antagonistic against naphthoquine and dihydroartemisinin. Pyronaridine blocks B-hematin formation in vitro and has inhibitory activity toward P-glycoprotein mediated drug resistance.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Storage class (TRGS 510): Non Combustible Solids

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
SK4920000

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles
Peer-Reviewed Papers
15

References

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