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P0543 Sigma-Aldrich

5-Pregnen-3β-ol-20-one-16α-carbonitrile

≥97%

Synonym: Pregnenolone-16α-carbonitrile

  • CAS Number 1434-54-4

  • Empirical Formula (Hill Notation) C22H31NO2

  • Molecular Weight 341.49

  •  MDL number MFCD00272045

  •  PubChem Substance ID 24898113

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Corticosteroid,
Quality Level   100
biological source   synthetic (organic)
assay   ≥97%
form   powder, crystals or chunks
application(s)   cell culture | mammalian: suitable
solubility   chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow (with heat)
shipped in   ambient
storage temp.   2-8°C
SMILES string   C[C@@]12[C@](C[C@@H](C#N)[C@@H]2C(C)=O)([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC1
InChI   1S/C22H31NO2/c1-13(24)20-14(12-23)10-19-17-5-4-15-11-16(25)6-8-21(15,2)18(17)7-9-22(19,20)3/h4,14,16-20,25H,5-11H2,1-3H3/t14-,16-,17+,18-,19-,20-,21-,22-/m0/s1
InChI key   VSBHRRMYCDQLJF-ZDNYCOCVSA-N

Description

Application

5-Pregnen-3β-ol-20-one-16α-carbonitrile has been used:
• in the induction of cytochrome P450
• as pregnane X receptor (PXR) activator in human liver cell lines.

Packaging

100, 250 mg in poly bottle

50 mg in glass insert

Biochem/physiol Actions

Pregnenolone-16a-carbonitrile (PCN) is a glucocorticoid receptor antagonist and a PXR (pregnane X receptor) activator.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
TU4536500
Flash Point(F) 
199.9 °F - closed cup
Flash Point(C) 
> 93.3 °C - closed cup

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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