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P0865 Sigma-Aldrich

N-(3-Pyridyl)indomethacinamide

≥98%

Synonym: N-3PyIA, N-(3-Pyridyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide

  • CAS Number 261766-29-4

  • Empirical Formula (Hill Notation) C24H20N3O3Cl

  • Molecular Weight 433.89

  •  MDL number MFCD02683393

  •  PubChem Substance ID 329820062

  •  NACRES NA.77

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Properties

Related Categories A to C, Application Index, Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
Quality Level   200
assay   ≥98%
form   powder
solubility   chloroform: 10 mg/mL to clear, colorless to light yellow
shipped in   wet ice
storage temp.   −20°C
SMILES string   COc1ccc2n(c(C)c(CC(=O)Nc3cccnc3)c2c1)C(=O)c4ccc(Cl)cc4
InChI   1S/C24H20ClN3O3/c1-15-20(13-23(29)27-18-4-3-11-26-14-18)21-12-19(31-2)9-10-22(21)28(15)24(30)16-5-7-17(25)8-6-16/h3-12,14H,13H2,1-2H3,(H,27,29)
InChI key   DTAPHQYAZUTCIG-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Potent and selective reversible cyclooxygenase-2 (COX-2) inhibitor (IC50 = 0.1 μM, human recombinant); about 300-fold less potent as an inhibitor of human recombinant COX-1. Not as selective with natural ovine COX (IC50 = 75 μM for COX-1 and 50 μM for COX-2).

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
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