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P118 Sigma-Aldrich

Phaclofen

solid

Synonym: 3-Amino-2-(4-chlorophenyl)propanephosphonic acid

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Properties

Related Categories Antagonists, Cell Biology, Cell Signaling and Neuroscience, GABAergics, Neuroscience,
InChI Key   VSGNGLJPOGUDON-UHFFFAOYSA-N
form   solid
impurities   ≥97% (NMR)
color   white
solubility   0.1 M HCl: 13.3 mg/mL
  methanol: 19.3 mg/mL
  DMSO: insoluble
Gene Information   human ... GABBR1(2550), GABBR2(9568)

Description

General description

Phaclofen is a phosphonic acid derivative of baclofen.

Application

Phaclofen has been used to block GABAB receptor.

Packaging

5, 25, 100 mg in glass bottle

Biochem/physiol Actions

Phaclofen plays a vital role in identifying the physiological importance of central and peripheral bicuculline-insensitive receptors with which GABA and (−) baclofen interact. Phaclofen acts as a GABAB receptor antagonist. Phaclofen has an ability to reversibly block the late, bicuculline resistant, K+ dependent inhibitory postsynaptic potential (IPSP) logged in projection cells of the cat and rat dorsal lateral geniculate nucleus and in rat hippocampal CA1 pyramidal neurons.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. P118.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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