P215 Sigma-Aldrich

PD 98,059


Synonym: 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one, PD98059




PD 98,059 has been used:
• in growth medium as a mitogen-activated protein (MAP) kinase inhibitor, in order to study the secondary messengers involved in the effect of D1-like receptors
• in calcium-free RPMI (Roswell park memorial institute)-1640 medium to study its effect on inflammation, proliferation and differentiation in human epidermal keratinocyte cell line in conjunction of cystic fibrosis transmembrane conductance regulator (CFTR) knockdown
• in culture medium for cell migration assay


1, 5 mg in glass bottle

Biochem/physiol Actions

PD 98,059 is a flavonoid and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock. It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Sold with permission of Warner Lambert Company.

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 


Certificate of Analysis


Certificate of Origin


Milli-Q® Water Purification Solutions
Protocols & Articles


EGF Signaling: Tracing Cancer's Path

The epidermal growth factor (EGF) family is a group of structurally related proteins that regulate cell proliferation, migration and differentiation via tyrosine kinase receptors on target cells. The...
Keywords: Apoptosis, Cancer, Cell proliferation, Cloning, Gene expression, Growth factors, Ligands, Morphogenesis, Phosphorylations, Transcription, Transduction, transformation

The Role of Inflammation in Neurodegeneration

It is well established that the brain can sense and react to peripheral insults through the rapid induction of fever and other neuroendocrine changes in response to events such as infection and tissu...
Scott Hauser, Technology Transfer Specialist, Sigma® Life Science
Biofiles, Vol. 8, No. 19
Keywords: Adhesion, Central Nervous System, Diseases, Gene expression, Inflammation, Neurodegenerative Diseases, Reductions

Peer-Reviewed Papers


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