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P3510 Sigma-Aldrich

Papaverine hydrochloride

powder

Synonym: 6,7-Dimethoxy-1-veratrylisoquinoline hydrochloride

  • CAS Number 61-25-6

  • Empirical Formula (Hill Notation) C20H21NO4 · HCl

  • Molecular Weight 375.85

  •  Beilstein Registry Number 3921435

  •  EC Number 200-502-1

  •  MDL number MFCD00012745

  •  PubChem Substance ID 24278152

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Properties

Related Categories Antitumor Agents, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cancer Research, Cell Biology,
InChI Key   UOTMYNBWXDUBNX-UHFFFAOYSA-N
assay   ≥98%
form   powder
color   white
solubility   H2O: 25 mg/mL
Gene Information   human ... PDE4B(5142)

Description

Biochem/physiol Actions

Smooth muscle relaxant and cerebral vasodilator; phosphodiesterase inhibitor.

Papaverine is originally used to resolve male impotence.

Packaging

5, 25, 100 g in poly bottle

Application

Papaverine hydrochloride has been used:
• in oxygenated Krebs solution for tissue mechanics analysis
• as a vasodilator in heparinized horse serum in tissue uptake technique
• as an inhibitor of H-MPP+ uptake into stably transfected 293 cells expressing either extraneuronal monoamine transporter (EMT) human or EMT rat

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

Papaverine hydrochloride belongs to the group of benzylisoquinoline alkaloid. It is obtained from opium poppy.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
1

Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cyclic Nucleotides

Transmission of an extracellular signal across the cell membrane is initiated by activation of many types of hormone and neurotransmitter receptors, such as G-protein coupled receptors (GPCRs), and c...
Keywords: Antivirals, Cancer, Cardiovascular, Cellular processes, Diabetes, Diseases, Hormones, Neurotransmitters

Peer-Reviewed Papers
15

References

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