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P3755 Sigma-Aldrich

6-Propyl-2-thiouracil

enzyme inhibitor

Synonym: 2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone, 4-Hydroxy-2-mercapto-6-propylpyrimidine

  • CAS Number 51-52-5

  • Empirical Formula (Hill Notation) C7H10N2OS

  • Molecular Weight 170.23

  •  Beilstein/REAXYS Number 130039

  •  EC Number 200-103-2

  •  MDL number MFCD00006041

  •  PubChem Substance ID 24898446

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Properties

Related Categories Biochemicals and Reagents, Nucleoside Analogs, Nucleosides, Nucleotides, Oligonucleotides More...
description   enzyme inhibitor
InChI Key   KNAHARQHSZJURB-UHFFFAOYSA-N
mp   218-220 °C (lit.)

Description

Application

6-Propyl-2-thiouracil has been used as a screening agent for testing the intensity of taste by labeled magnitude scale (LMS).

6-Propyl-2-thiouracil is a thyreostatic (thyroid hormone) agent that may be used as a reference material in thyreostatic drug separation and detection technologies such as capillary electrophoresis, HPLC, or gas chromatography.

Packaging

10, 25, 100 g in glass bottle

Biochem/physiol Actions

6-Propyl-2-thiouracil (6-PTU), a potential inhibitor of D1 iodothyronine deiodinase, is involved in the deiodination of iodothyronines. It is an uncompetitive inhibitor of iodothyronine substrates.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
YR1400000
Flash Point(F) 
572 °F
Flash Point(C) 
300 °C
Protocols & Articles

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Peer-Reviewed Papers
15

References

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