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P4157 Sigma-Aldrich

Phe-Arg β-naphthylamide dihydrochloride

cathepsin substrate

  • CAS Number 100929-99-5

  • Empirical Formula (Hill Notation) C25H30N6O2 · 2HCl

  • Molecular Weight 519.47

  •  MDL number MFCD00058046

  •  PubChem Substance ID 24898508

  •  NACRES NA.32

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Description

General description

Phe-Arg β-naphthylamide, a peptidomimetic compound, is an efflux pump inhibitor (EPI). It acts on the major multidrug resistance efflux transporters of Gram-negative bacteria. Phe-Arg -naphthylamide lowers fluoroquinolone resistance in Pseudomonas aeruginosa.

Application

Phe-Arg -naphthylamide dihydrochloride has been used to evaluate the contribution of efflux pumps to antimicrobial resistance. It has also been used for minimal inhibitory concentration testing in the presence of an efflux pump inhibitor.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Substrates

Substrate for dipeptidyl aminopeptidase I (cathepsin C).

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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