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P4236 Sigma-Aldrich

Cyclic Pifithrin-α hydrobromide

≥98% (HPLC)

Synonym: 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole hydrobromide, Cyclic PFT-α hydrobromide, Pifithrin-α, cyclic, QB102

  • CAS Number 511296-88-1

  • Empirical Formula (Hill Notation) C16H16N2S · HBr

  • Molecular Weight 349.29

  •  MDL number MFCD02683960

  •  PubChem Substance ID 24898515

  •  NACRES NA.77

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Properties

Related Categories Apoptosis Inhibitors, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ,
Quality Level   100
assay   ≥98% (HPLC)
solubility   DMSO: 20 mg/mL
shipped in   dry ice
storage temp.   −20°C
SMILES string   Br[H].Cc1ccc(cc1)-c2cn3c4CCCCc4sc3n2
InChI   1S/C16H16N2S.BrH/c1-11-6-8-12(9-7-11)13-10-18-14-4-2-3-5-15(14)19-16(18)17-13;/h6-10H,2-5H2,1H3;1H
InChI key   SGNCOAOESGSEOP-UHFFFAOYSA-N

Description

Application

Cyclic Pifithrin-α hydrobromide has been used as p53 inhibitor to study its role in cigarette smoke−induced apoptosis of pulmonary endothelial cells.

Packaging

5, 10 mg in glass bottle

Biochem/physiol Actions

A stable analog of Pifithrin-α (Product Code P4359) with similar biological activities and lower cellular toxicity.

Packaging

Protect from light.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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