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P4368 Sigma-Aldrich

Piericidin A from microbial source

>95% (HPLC), DMSO solution

Synonym: 2,6,9,11-Tridecatetraen-4-ol,13-(4-hydrox-5,6-dimethoxy-3-methyl-2-pyridyl)-3,5,7,11-tetramethyl-(all-E)-(4R,5R), 4-Pyridinol,2-(10-hydroxy-3,7,9,11-tetramethyl-2,5,7,11-tridecatetraenyl)-5,6-dimethoxy- [R-[R*,R*-(all-E)]]-3-methyl-, Piericidin A1, SN 198E, Shaoguamycin B

  • CAS Number 2738-64-9

  • Empirical Formula (Hill Notation) C25H37NO4

  • Molecular Weight 415.57

  •  MDL number MFCD01677956

  •  PubChem Substance ID 24898532

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Properties

Related Categories Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   BBLGCDSLCDDALX-LKGBESRRSA-N
assay   >95% (HPLC)
form   DMSO solution
shipped in   wet ice
storage temp.   2-8°C

Description

Packaging

100 μg in glass bottle

Biochem/physiol Actions

Piericidin A (PA), an insecticidal metabolite of Streptomyces mobaraensis is a potential quorum-sensing inhibitors (QSIs) that can destroy the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Hence it may be used as control agents of soft rot disease on potato tubers.

Piericidin A is a potent inhibitor of the mitochondrial and bacterial type I NADH-ubiquinone oxireductase (Complex I). It is considered to bind to the ubiquinone binding sites of the enzyme. Peiricidin A inactivation of complex I completely prevents NADH-induced proton translocation in the NADH-endogenous ubiquinone reductase reaction.

Safety & Documentation

Safety Information

RIDADR 
NA 1993 / PGIII
WGK Germany 
1
Flash Point(F) 
185 °F
Flash Point(C) 
85 °C

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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