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P4394 Sigma-Aldrich

cis-Diammineplatinum(II) dichloride

crystalline

Synonym: cis-Dichlorodiammine platinum(II), cis-Platinum(II) diammine dichloride, Cisplatin

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Description

Application

cis-Diammineplatinum(II) dichloride has been used:
•  in cell viability measurement in cochlear explants
•  in the inhibition of cell proliferation and chemosensitivity in ovarian cancer cell lines
•  in MTT [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] cell viability assay in oral squamous cell carcinoma

Packaging

1 g in glass bottle

100, 250 mg in glass bottle

25 mg in glass insert

Biochem/physiol Actions

Potent chemoimmunotherapeutic drug; stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin-treated macrophages show increased antigen presentation function in vitro. Treatment increased cellular NF-κB content and translocation in macrophages. Cisplatin effects are regulated by kinases, phosphatases, and Ca2+/calmodulin. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand crosslinks.

Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Corden. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 3288 6.1 / PGII
WGK Germany 
3
RTECS 
TP2450000

Documents

Certificate of Analysis

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Certificate of Origin

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Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
What is the toxicity of Cisplatin, Product P4394?
This information can be found on the MSDS Section 11.
How can solutions ofCisplatin, Product P4394, be stored?
Sterile solutions in 0.9% sodium chloride protected from light are stable for 28 days at room temperature.
What is the best solvent to use for Cisplatin, Product P4394?
Pharmaceutical injections of cisplatin are in 0.9% sodium chloride at 1 mg/ml. A 0.1% solution in 0.9% sodium chloride solution has a pH range of 4.5-6.0 immediately after preparation and can be adjusted with HCl.
What is the half-life ofCisplatin, Product P4394, in DMSO?
At 37 °C, the half-life of cisplatin in DMSO is 60 minutes. In vivo the half-life of cisplatin is approximately 30 minutes.
Why should DMSO not be used as a solvent for cis-Diammineplatinum (II) dichloride?
The divalent platinum has a high affinity for sulfur donor ligands and this will displace the chloride. The use of DMSO as a solvent affects the instability of cisplatin and can affect biological activity. Sundquist, W. I., et al., Inorg. Chem. 26:1524-1528, 1987.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
My question is not addressed here, how can I contact Technical Service for assistance?
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Protocols & Articles

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Peer-Reviewed Papers
15

References

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