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P7127 Sigma-Aldrich

Phospho(enol)pyruvic acid monopotassium salt

≥97% (enzymatic)

Synonym: 2-(Phosphonooxy)-2-propenoic acid monopotassium salt, PEP-K, mono-Potassium phosphoenolpyruvate

  • CAS Number 4265-07-0

  • Empirical Formula (Hill Notation) C3H4KO6P

  • Molecular Weight 206.13

  •  Beilstein/REAXYS Number 4603446

  •  EC Number 224-247-0

  •  MDL number MFCD00044476

  •  PubChem Substance ID 24898822

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Description

General description

Phospho(enol)pyruvic acid (PEP) acts as an inhibitor of hexokinase, phosphoglucose isomerase, phosphofructokinase and aldolase. It is a bifunctional carbohydrate, which exhibits antioxidant property. PEP may be a potential organ preservation agent in clinical transplantation.

Application

Phospho(enol)pyruvic acid monopotassium salt has been used:
• to maintain a constant concentration of adenosine triphosphate (ATP) for active gel assembly
• as a component in assay buffer for in vitro ATPase assay
• as a stock solution for optical trapping assay

Biochem/physiol Actions

Phospho(enol)pyruvic acid (PEP) is involved in glycolysis and gluconeogeneis. In glycolysis, PEP is metabolized by Pyruvate Kinase to yield pyruvate. In plants, PEP is involved in the formation of aromatic amino acids as well as in the carbon fixation pathway.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles

Articles

Aerobic Glycolysis and the Warburg Effect

The Warburg effect is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer ce...
Keywords: Aerobic, Cancer, Cell proliferation, Clinical, Glycolysis, PAGE, Phosphorylations, Transcription

Glycolysis Overview

Carbohydrates synthesized during photosynthesis act as the main storage molecules of solar energy. When ingested, complex carbohydrates are enzymatically hydrolyzed to monosaccharides, such as starch...
BioFiles 2007, 2.6, 4.
Keywords: Aldol reaction, Dehydration reaction, Glycolysis, Isomerizations, Metabolism, Metabolites, Metabolomics, Phosphorylations, Photosynthesis

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Peer-Reviewed Papers
15

References

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