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P7136 Sigma-Aldrich

Pyrazinecarboxamide

Synonym: Pyrazinamide, Pyrazinoic acid amide

  • CAS Number 98-96-4

  • Empirical Formula (Hill Notation) C5H5N3O

  • Molecular Weight 123.11

  •  Beilstein/REAXYS Number 112306

  •  EC Number 202-717-6

  •  MDL number MFCD00006132

  •  PubChem Substance ID 24278648

  •  NACRES NA.85

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Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antimycobacterial,
InChI Key   IPEHBUMCGVEMRF-UHFFFAOYSA-N
mp   189-191 °C (lit.)
solubility   H2O: soluble 50 mg/mL
Mode of action   cell membrane | interferes
antibiotic activity spectrum   mycobacteria

Description

Application

Pyrazinamide is used therapeutically as an antitubercular agent. Pyrazinamide is used to form polymeric copper complexes, create pyrazine carboxamide scaffolds useful as FXs inhibitors, and as a component of mycobacteria identification kits. It is used to study liver toxicity prevention and mechanisms of resistance .

Packaging

10, 25, 100 g in poly bottle

Biochem/physiol Actions

The active moiety of pyrazinamide is pyrazinoic acid (POA). POA is thought to disrupt membrane energetics and inhibit membrane transport function at acid pH in Mycobacterium tuberculosis. Iron enhances the antituberculous activity of pyrazinamide . Pyrazinamide and its analogs have been shown to inhibit the activity of purified FAS I.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
UQ2275000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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