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P7888 Sigma-Aldrich

DL-Propargylglycine

cystathionine γ-lyase inhibitor

Synonym: 2-Amino-4-pentynoic acid, PAG

  • CAS Number 64165-64-6

  • Empirical Formula (Hill Notation) C5H7NO2

  • Molecular Weight 113.11

  •  MDL number MFCD00056728

  •  eCl@ss 32160406

  •  PubChem Substance ID 24898885

  •  NACRES NA.26

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Properties

Related Categories Amino Acids, Biochemicals and Reagents, I - Z, Modified Amino Acids
storage temp.   −20°C
SMILES string   NC(CC#C)C(O)=O
InChI   1S/C5H7NO2/c1-2-3-4(6)5(7)8/h1,4H,3,6H2,(H,7,8)
InChI key   DGYHPLMPMRKMPD-UHFFFAOYSA-N

Description

Biochem/physiol Actions

DL-Propargylglycine (PAG) is an irreversible inhibitor of the enzyme cystathionine γ-lyase (GCL), a key enzyme involved in glutathione synthesis and the metabolic transsulfuration pathway which regulates homocysteine concentration and mediates cysteine synthesis. Treatment of animal disease models with PAG was shown to alleviate symptoms of diseases that impair the formation or action of hydrogen sulfide (H2S).

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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