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  • P8877 - D-(−)-3-Phosphoglyceric acid disodium salt

P8877 Sigma-Aldrich

D-(−)-3-Phosphoglyceric acid disodium salt

≥93%, powder

Synonym: (−)-Disodium D-3-phosphoglycerate, D-Glycerate 3-phosphate disodium salt

  • CAS Number 80731-10-8

  • Empirical Formula (Hill Notation) C3H5Na2O7P

  • Molecular Weight 230.02

  •  Beilstein/REAXYS Number 3767836

  •  MDL number MFCD00069569

  •  PubChem Substance ID 24898988

  •  NACRES NA.25



Related Categories Aerobic Glycolysis (the Warburg Effect), Biochemicals and Reagents, Cancer Metabolism, Cancer Research, Carbohydrate,
Quality Level   200
biological source   synthetic (inorganic)
assay   ≥93%
form   powder
color   white
solubility   H2O: 50 mg/mL, clear, colorless to faintly yellow
greener alternative category   Re-engineered
storage temp.   −20°C
SMILES string   [Na+].[Na+].O[C@H](COP(O)([O-])=O)C([O-])=O
InChI   1S/C3H7O7P.2Na/c4-2(3(5)6)1-10-11(7,8)9;;/h2,4H,1H2,(H,5,6)(H2,7,8,9);;/q;2*+1/p-2/t2-;;/m1../s1



D-(-)-3-Phosphoglyceric acid disodium salt has been used in a study to assess the phosphorylation of glyceric acid in aqueous solution. It has also been used in a study to characterize a glutathione- and NAD-dependent arsenate reduction linked to glycolysis.


1, 5 g in glass bottle

10 mg in glass bottle

Biochem/physiol Actions

3-Phosphoglyceric acid is an intermediate in glycolysis. It also a precursor in the formation of serine.

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
NONH for all modes of transport
WGK Germany 


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles


Aerobic Glycolysis and the Warburg Effect

The Warburg effect is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer ce...
BioFiles v7 n4
Keywords: Aerobic, Cancer, Cell proliferation, Clinical, Glycolysis, Phosphorylations, Transcription

Calvin Cycle

The Calvin cycle is a more complex process used by algae, plants and photosynthetic bacteria to convert carbon dioxide and water into carbohydrate and molecular oxygen with the aid of sunlight. The l...
BioFiles 2007, 2.6, 27.
Keywords: Aldol condensation, Biofiles, Catalysis, Condensations, Isomerizations, Phosphorylations, Reductions

Glycolysis via the Embden-Meyerhof-Parnas glycolytic pathway

Glycolysis is the almost universal pathway that converts glucose into pyruvate along with the formation of nicotinamide adenine dinucleotide (NADH) and adenosine triphosphate (ATP). It primarily occu...
Keywords: Aerobic, Aldol reaction, Anaerobic, Dehydration reaction, Fermentation, Glycolysis, Isomerizations, Metabolism, Metabolites, Metabolomics, Oxidations, Phosphorylations, Photosynthesis

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Monosaccharide Biosynthesis

Each monosaccharide has its own interesting metabolism. The pathway by which a monosaccharide is made, is not the reverse of its degradation pathway (see Figure 4).
BioFiles 2007, 2.6, 21.
Keywords: Addition reactions, Carboxylations, Catalysis, Condensations, Decarboxylations, Degradations, Metabolic Pathways, Metabolism, Metabolites, Phosphorylations, Reductions

Nucleotide Synthesis in Cancer Cells

Neoplastic cells are highly dependent on the de novo synthesis of nucleotides to maintain sufficient pools to support DNA replication and the production of RNA. The metabolic pathways supporting nucl...
BioFiles v7 n4
Keywords: Cancer, Catalysis, Citric Acid Cycle, DNA replication, Gene expression, Glycolysis, Metabolic Pathways, Metabolism, Metabolites, Nucleotide Synthesis, Pentose phosphate pathway, Pyrimidine synthesis

Peer-Reviewed Papers


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