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P9018 Sigma-Aldrich

Phorbol 12,13-didecanoate

solid

Synonym: PDD, Phorbol 12,13-dicaprinate

  • CAS Number 24928-17-4

  • Empirical Formula (Hill Notation) C40H64O8

  • Molecular Weight 672.93

  •  Beilstein/REAXYS Number 6036113

  •  MDL number MFCD00065449

  •  PubChem Substance ID 24899003

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Properties

form   solid
color   white
solubility   DMSO: soluble
  ethanol: soluble
  methanol: soluble
storage temp.   −20°C
SMILES string   [H][C@@]12C=C(CO)C[C@]3(O)C(=O)C(C)=C[C@@]3([H])[C@@]1(O)[C@H](C)[C@@H](OC(=O)CCCCCCCCC)[C@]4(OC(=O)CCCCCCCCC)C2C4(C)C

Description

General description

More potent than phorbol myristate acetate as an inflammatory agent, but weaker as a tumor promoting agent

Biochem/physiol Actions

Strong NO promoter; potent activator of protein kinase C; promotes iNOS expression in cultured hepatocytes.

Caution

Photosensitive

Reconstitution

A stock solution cannot be made in aqueous media; dissolve in a water-miscible organic solvent before dilution to working concentrations in aqueous media.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
GZ0653000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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