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P9143 Sigma-Aldrich

Phorbol 12,13-diacetate

powder

Synonym: PDA

  • CAS Number 24928-15-2

  • Empirical Formula (Hill Notation) C24H32O8

  • Molecular Weight 448.51

  •  Beilstein/REAXYS Number 2317312

  •  MDL number MFCD00036735

  •  PubChem Substance ID 24899011

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Protein Kinase Activators, Protein Kinase C (PKC),
form   powder
color   white
solubility   H2O: soluble
storage temp.   −20°C
SMILES string   C[C@@H]1[C@@H](OC(C)=O)[C@]2(OC(C)=O)[C@H]([C@@H]3C=C(CO)C[C@@]4(O)[C@@H](C=C(C)C4=O)[C@@]13O)C2(C)C
InChI   1S/C24H32O8/c1-11-7-17-22(29,19(11)28)9-15(10-25)8-16-18-21(5,6)24(18,32-14(4)27)20(31-13(3)26)12(2)23(16,17)30/h7-8,12,16-18,20,25,29-30H,9-10H2,1-6H3/t12-,16+,17-,18-,20-,22-,23-,24-/m1/s1
InChI key   OMHXSAMFEJVCPT-XQOWHXTBSA-N

Description

General description

Phorbol ester with enhanced hydrophilicity.

Packaging

5 mg in ampule

Biochem/physiol Actions

Activates protein kinase C.

Other Notes

Less potent but more water soluble than phorbol 12,13-dibutyrate.

Caution

Photosensitive.

Reconstitution

Although having aqueous solubility, it is recommended that this compound first be dissolved in a water miscible organic solvent before dilution to working concentrations in aqueous media.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Target organs 
Respiratory system
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
WGK 3
RTECS 
GZ0651000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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