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P9178 Sigma-Aldrich

Prochlorperazine dimaleate salt

  • CAS Number 84-02-6

  • Empirical Formula (Hill Notation) C20H24ClN3S · 2C4H4O4

  • Molecular Weight 606.09

  •  EC Number 201-511-3

  •  MDL number MFCD00069330

  •  PubChem Substance ID 57654570

  •  NACRES NA.77

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Properties

Related Categories Antagonists - Dopaminergics, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents,
Quality Level   200
solubility   H2O: slightly soluble 0.3 mg/mL
  45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.3 mg/mL
  methanol: soluble
originator   GlaxoSmithKline
SMILES string   OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1
InChI   1S/C20H24ClN3S.2C4H4O4/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24;2*5-3(6)1-2-4(7)8/h2-3,5-8,15H,4,9-14H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
InChI key   DSKIOWHQLUWFLG-SPIKMXEPSA-N
Gene Information   human ... DRD2(1813)

Description

Packaging

5 g in poly bottle

Biochem/physiol Actions

Prochlorperazine is an anti-nausea and neuroleptic agent. It is known to cause neuropsychiatric side effects. Prochlorperazine inhibits the action of dopamine in the central nervous system. It acts as an antiemetic drug and prevents vomiting and stimulates sleep. Prochlorperazine is useful as a tranquilizer in the treatment of schizophrenia and nonpsychotic anxiety.

Phenothiazine antipsychotic; D2 dopamine receptor antagonist; antispasmodic

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
SO3150000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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