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PZ0008 Sigma-Aldrich

Celecoxib

≥98% (HPLC)

Synonym: 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide, CJ-016377, CP-598107, PF-00345549, PHA-00846533, SC-58635, YM-177

  • CAS Number 169590-42-5

  • Empirical Formula (Hill Notation) C17H14F3N3O2S

  • Molecular Weight 381.37

  •  MDL number MFCD00941298

  •  PubChem Substance ID 329823677

  •  NACRES NA.77

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, C-CH,
InChI Key   RZEKVGVHFLEQIL-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
color   white to off-white
solubility   DMSO: >20 mg/mL
originator   Pfizer
storage temp.   room temp

Description

Application

Celecoxib has been used as an inhibitor of cyclooxygenase-2 (COX-2) in pre-treatment and in the chemotherapy regimen in bladder cancer cells. It has also been used in studying its inhibitory effect on the cell viability and proliferation in human prostate cancer cell line (PC-3).

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Celecoxib is a non-steroidal, anti-inflammatory drug (NSAID) and a cyclooxygenase-2 (COX-2) selective inhibitor. Celecoxib is at least 10-20 times more selective for COX-2 over COX-1.

Celecoxib is majorly bound to plasma proteins and is eliminated from liver via cytochrome P450 metabolic pathway. Celecoxib is recommended drug for the management of inflammation in osteoarthritis and rheumatoid arthritis. It may be effective in treating colorectal cancer in combination with chemoradiotherapy.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here to learn more.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. PZ0008.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
DB2944937

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for ADME/Tox

A significant number of drugs that fail in clinical trials have been associated with safety issues, including unexpected drug-drug interactions (DDI) or lack of efficacy due to poor pharmacokinetics....
Keywords: Absorption, Bioactive small molecules, Clinical, Metabolism

Discover Bioactive Small Molecules for Lipid Signaling Research

Within mammalian cells, a multitude of lipid compounds are found with a variety of cellular functions, including structural components of cell membranes and as second messengers in cell signaling pat...
Keywords: Absorption, Atomic absorption spectroscopy, Cancer, Cardiovascular, Cell signaling, Diabetes, Digestions, Diseases, Growth factors, Hormones, Inflammation, Lipid Metabolism, Lipid signaling, Metabolism

Pfizer Compounds for Lipid Signaling

From our library of Articles, Sigma-Aldrich presents Pfizer Compounds for Lipid Signaling

The Role of Inflammation in Neurodegeneration

It is well established that the brain can sense and react to peripheral insults through the rapid induction of fever and other neuroendocrine changes in response to events such as infection and tissu...
Scott Hauser, Technology Transfer Specialist, Sigma® Life Science
Biofiles, Vol. 8, No. 19
Keywords: Adhesion, Central Nervous System, Diseases, Gene expression, Inflammation, Neurodegenerative Diseases, Reductions

Peer-Reviewed Papers
15

References

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