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PZ0016 Sigma-Aldrich

Dofetilide

≥98% (HPLC)

Synonym: N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide, UK-68798

  • CAS Number 115256-11-6

  • Empirical Formula (Hill Notation) C19H27N3O5S2

  • Molecular Weight 441.56

  •  MDL number MFCD00869707

  •  PubChem Substance ID 329823685

  •  NACRES NA.77

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   IXTMWRCNAAVVAI-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
color   white to off-white
solubility   DMSO: >20 mg/mL
originator   Pfizer
storage temp.   room temp

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Dofetilide is a Class III antiarrhythmic and hERG channel blocker. Dofetilide selectively blocks the rapid component of the delayed rectifier outward potassium current (IKr).

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here to learn more.

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

This compound was developed by Pfizer for Ion Channel research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
nwg

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Ion Channels Research

Ion transport across the relatively impermeable lipid bilayer of the cell membrane is accomplished via membrane proteins known as ion channels, pumps and transporters. Ion channels are gated pores an...
Keywords: Biological processes, Cell signaling, Diseases, Hormones, Ligands, Neurotransmitters

LC/MS Analysis of Antiarrhythmics on Ascentis® Express Biphenyl

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Antiarrhythmics on Ascentis® Express Biphenyl
Keywords: High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry

LC/MS Analysis of Cardiac Depressants on Ascentis® Express Biphenyl

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Cardiac Depressants on Ascentis® Express Biphenyl
Keywords: High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry

Pfizer Compounds for Ion Channels

From our library of Articles, Sigma-Aldrich presents Pfizer Compounds for Ion Channels

Peer-Reviewed Papers
15

References

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