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PZ0309 Sigma-Aldrich

PF-04634817 succinate

≥98% (HPLC)

Synonym: 1,5-Anhydro-2,3-dideoxy-4-O-methyl-3-[[(1R,3S)-3-(1-methylethyl)-3-[[(1S,4S)-5-[6-(trifluoromethyl)-4-pyrimidinyl]-2,5-diazabicyclo[2.2.1]hept-2-yl]carbonyl]cyclopentyl]amino]-D-erythro-pentitol succinate, PF 04634817 succinate

  • CAS Number 1228111-63-4 (free base)

  • Empirical Formula (Hill Notation) C25H36F3N5O3 · C4H6O4

  • Molecular Weight 629.67

  •  PubChem Substance ID 329823829

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Chemokine Inhibitors,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
mfr. no.   Pfizer®
color   white to beige
solubility   H2O: 30 mg/mL, clear
originator   Pfizer
storage temp.   room temp
SMILES string   CC(C)[C@@]1(C(N2C[C@@]3([H])N(C4=NC=NC(C(F)(F)F)=C4)C[C@]2([H])C3)=O)C[C@H](N[C@H]5CCOC[C@H]5OC)CC1.O=C(CCC(O)=O)O
InChI   1S/C25H36F3N5O3.C4H6O4/c1-15(2)24(6-4-16(10-24)31-19-5-7-36-13-20(19)35-3)23(34)33-12-17-8-18(33)11-32(17)22-9-21(25(26,27)28)29-14-30-22;5-3(6)1-2-4(7)8/h9,14-20,31H,4-8,10-13H2,1-3H3;1-2H2,(H,5,6)(H,7,8)/t16-,17+,18+,19+,20-,24+;/m1./s1
InChI key   WRPPUEHVLSHXJG-HTQYHTRRSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

PF-04634817 is a potent and selective antagonist of CC chemokine receptor 2 and 5 (CCR2/5).

Other Notes

This compound was developed by Pfizer for Cytokines & Growth Factors research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

Pfizer is a registered trademark of Pfizer, Inc.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Pfizer Compounds for Cytokines and Growth Factors

From our library of Articles, Sigma-Aldrich presents Pfizer Compounds for Cytokines and Growth Factors

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