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PZ0342 Sigma-Aldrich

PF-6274484

≥98% (HPLC)

Synonym: N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Epidermal Growth Factor Receptor (EGFR),
Quality Level   100
assay   ≥98% (HPLC)
form   powder
mfr. no.   Pfizer®
color   white to light brown
solubility   DMSO: 20 mg/mL, clear
originator   Pfizer
storage temp.   room temp
SMILES string   FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=CC(OC)=C(NC(C=C)=O)C=C32
InChI   1S/C19H16ClFN4O/c1-4-11(2)24-17-8-13-16(9-18(17)26-3)22-10-23-19(13)25-12-5-6-15(21)14(20)7-12/h4-10,24H,1-2H2,3H3,(H,22,23,25)
InChI key   DTMQCGFVWWBONL-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

PF-6274484 is an irreversible EGFR kinase inhibitor that covalently reacts with active-site cysteine residues in the ATP binding pocket. PF-6274484 inhibits autophosphorylation of both wild type and mutant EGFR in tumor cells with IC50 values of 5.8 nM and 6.6 nM, respectively.

Other Notes

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

Pfizer is a registered trademark of Pfizer, Inc.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Pfizer Compounds for Kinase Phosphatase Biology

From our library of Articles, Sigma-Aldrich presents Pfizer Compounds for Kinase Phosphatase Biology

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