• USA Home
  • PZ0374 - PF-06446846 hydrochloride

EMAIL THIS PAGE TO A FRIEND
PZ0374 Sigma-Aldrich

PF-06446846 hydrochloride

≥98% (HPLC)

Synonym: N-(3-Chloropyridin-2-yl)-N-((3R)-piperidin-3-yl)-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide hydrochloride

  • CAS Number 1632250-50-0

  • Empirical Formula (Hill Notation) C22H20ClN7O · xHCl

  • Molecular Weight 433.89 (free base basis)

Purchase

Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, P-PH
assay   ≥98% (HPLC)
form   powder
optical activity   [α]/D -60 to -50°, c = 1 in methanol
color   white to beige
solubility   H2O: 2 mg/mL, clear
storage temp.   room temp

Description

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

Biochem/physiol Actions

PF-06446846 is a selective orally active PCSK9 inhibitor that appears to act by causing the ribosome to stall when synthesizing PCSK9. PCSK9 binds to the LDL receptor, preventing it from removing LDL cholesterol from the blood. PF-06446846 was found to reduce plasma PCSK9 and total cholesterol levels in rats.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?