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R0533 Sigma-Aldrich

Rifapentine

Synonym: DL 473

  • CAS Number 61379-65-5

  • Empirical Formula (Hill Notation) C47H64N4O12

  • Molecular Weight 877.03

  •  EC Number 262-743-9

  •  PubChem Substance ID 329823987

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Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Mechanism of Action,
InChI Key   WDZCUPBHRAEYDL-OABFQHKQSA-N
assay   ≥93%
form   powder
solubility   methanol: 2 mg/mL, clear, red to red-brown
Mode of action   enzyme | inhibits
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
  mycobacteria
shipped in   wet ice
storage temp.   2-8°C

Description

General description

Chemical structure: macrolide

Packaging

25, 100 mg in poly bottle

Application

Rifapentine is an antibiotic clinically used to treat tuberculosis. It is used in tuberculosis research.

Biochem/physiol Actions

Rifapentine is a semisynthetic derivative of rifampicin with antibacterial activity against Gram-positive and Gram-negative bacteria and against Mycobacterium tuberculosis. Rifapentine inhibits DNA-dependant RNA polymerase and prevents RNA transcription. It interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme.

Semisynthetic derivative of rifampicin with antibacterial activity against Gram-positive and Gram-negative bacterial and against Mycobacterium tuberculosis. Rifapentine inhibits DNA-dependant RNA polymerase and prevents RNA transcription.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
JQ0902000

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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