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R9157 Sigma-Aldrich

Ro 4-1284

≥98% (HPLC)

Synonym: 2-Hydroxy-2-ethyl-3-isobutyl-9,10-dimethoxy-1,2,3,4,5,6,7-hexahydrobenzo[a]chinolizine

  • CAS Number 303-75-3

  • Empirical Formula (Hill Notation) C21H33NO3

  • Molecular Weight 347.49

  •  MDL number MFCD01663028

  •  PubChem Substance ID 329824045

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥98% (HPLC)
form   solid
solubility   DMSO: 16 mg/mL
originator   Roche
storage temp.   2-8°C
SMILES string   CCC1(O)CC2N(CCc3cc(OC)c(OC)cc23)CC1CC(C)C
InChI   1S/C21H33NO3/c1-6-21(23)12-18-17-11-20(25-5)19(24-4)10-15(17)7-8-22(18)13-16(21)9-14(2)3/h10-11,14,16,18,23H,6-9,12-13H2,1-5H3
InChI key   TUNMGCULOKMBNJ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Ro 4-1284 is a reversible VMAT2 inhibitor.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
GHS09  GHS09
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Biogenic Amine Transporters

Following vesicular release, the biogenic amine neurotransmitters, norepinephrine (A7257), dopamine (H8502) and serotonin (H9523), are removed from the extracellular space by selective and pharmacolo...
Keywords: Anti-depressants, Atomic absorption spectroscopy, Clinical, Cloning, Gene expression, Ligands, Neurotransmission, Neurotransmitters, Parkinson Disease, Phosphorylations, Schizophrenia

Peer-Reviewed Papers
15

References

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