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S0693 Sigma-Aldrich

SB 204741

>98% (HPLC)

Synonym: N-(1-Methyl-1H-5-indolyl)-N′-(3-methyl-5-isothiazolyl)urea

  • CAS Number 152239-46-8

  • Empirical Formula (Hill Notation) C14H14N4OS

  • Molecular Weight 286.35

  •  MDL number MFCD00923644

  •  PubChem Substance ID 24278321

  •  NACRES NA.77

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Properties

Related Categories Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents,
Quality Level   100
assay   >98% (HPLC)
form   solid
color   off-white to tan
solubility   DMSO: soluble >20 mg/mL
originator   GlaxoSmithKline
storage temp.   2-8°C
SMILES string   Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
InChI   1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
InChI key   USFUFHFQWXDVMH-UHFFFAOYSA-N
Gene Information   human ... DRD2(1813), DRD3(1814), DRD5(1816), HTR1E(3354), HTR2A(3356), HTR2B(3357), HTR2C(3358)
rat ... Adra1a(29412), Gabra2(29706), Htr1a(24473), Htr2b(29581), Htr3a(79246)

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

5-HT2B serotonin receptor antagonist.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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