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S1141 Sigma-Aldrich

Spermine tetrahydrochloride

BioReagent, for molecular biology

Synonym: N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride

  • CAS Number 306-67-2

  • Empirical Formula (Hill Notation) C10H26N4 · 4HCl

  • Molecular Weight 348.18

  •  Beilstein/REAXYS Number 3911771

  •  EC Number 206-189-8

  •  MDL number MFCD00012914

  •  PubChem Substance ID 24899462

  •  NACRES NA.52

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Properties

Related Categories DNA & RNA Purification, Molecular Biology, Plant Biotechnology, Plant Molecular Biology, Plant Nucleic Acid Purification,
Quality Level   300
grade   for molecular biology
product line   BioReagent
form   solid
mp   310-311 °C (dec.) (lit.)
solubility   H2O: soluble 100 mg/mL, clear, colorless to light yellow
foreign activity   DNase, RNase, protease, NICKase, none detected
storage temp.   room temp
SMILES string   Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN
InChI   1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
InChI key   XLDKUDAXZWHPFH-UHFFFAOYSA-N

Description

General description

Spermine is a polyamine involved in cellular metabolism and DNA stabilization. In molecular biology it can be used in buffers for purification of DNA.

Application

Used to precipitate DNA from low salt aqueous buffers.

Biochem/physiol Actions

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
EJ7230000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Spermine tetrahydrochloride for molecular biology

CAS RN 306-67-2 EC 206-189-8 Synonyms: N, N’-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
Keywords: Biochemistry, Buffers, Building blocks, Crystallization, Mass spectrometry, Melting, Molecular biology, Precipitation

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Peer-Reviewed Papers
15

References

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S0266 Spermidine, BioReagent, for molecular biology, suitable for cell culture, ≥98%

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