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S1563 Sigma-Aldrich

SKF-86466 hydrochloride

solid, ≥98% (HPLC)

Synonym: 6-Chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine hydrochloride

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Properties

Related Categories Adrenergics, Adrenergics - Antagonists, Antagonists- Adrenergics, Biochemicals and Reagents, Cell Biology,
assay   ≥98% (HPLC)
form   solid
color   white
solubility   H2O: 24 mg/mL
SMILES string   Cl.CN1CCc2cccc(Cl)c2CC1
InChI   1S/C11H14ClN.ClH/c1-13-7-5-9-3-2-4-11(12)10(9)6-8-13;/h2-4H,5-8H2,1H3;1H
InChI key   JKQKVNMNAIFCFS-UHFFFAOYSA-N
Gene Information   human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Description

Application

SKF 86466 was used to study adrenoceptor signaling in rat limbic seizure models.

Biochem/physiol Actions

SKF 86466 binds specifically to α2-adrenoceptors at pre- and post-junctional sites but was also reported to antagonize α1-aderenoceptors in humans. The structural similarity of receptors enables SKF 86466 binding to 5-HT1A receptors.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Alpha 2 Adrenoreceptor Modulators

α2-Adrenoceptors are widely distributed and are activated by norepinephrine (A7257, A0937), released from sympathetic nerve terminals or by epinephrine (E4250, E4375), released from the adrenal medul...
Keywords: Analgesics, Atomic absorption spectroscopy, Cardiovascular, Eliminations, Gene expression, Genetic, Neurotransmission, Neurotransmitters, Transduction

Peer-Reviewed Papers
15

References

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