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S168 Sigma-Aldrich

N-Allyl-(±)-SKF-38393 hydrobromide

solid, ≥98% (HPLC)

Synonym: (±)-SKF-77434 hydrobromide, (±)-7,8-Dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

  • CAS Number 300561-58-4

  • Empirical Formula (Hill Notation) C19H21NO2 · HBr

  • Molecular Weight 376.29

  •  MDL number MFCD00243077

  •  PubChem Substance ID 24277936

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Properties

Related Categories A-AM, Agonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents,
assay   ≥98% (HPLC)
form   solid
storage condition   protect from light
color   white to off-white
solubility   ethanol: 3.2 mg/mL
  DMSO: >50 mg/mL
  H2O: 6.0 mg/mL
  0.1 M HCl: 6.3 mg/mL
storage temp.   2-8°C
SMILES string   Br[H].Oc1cc2CCN(CC=C)CC(c3ccccc3)c2cc1O
InChI   1S/C19H21NO2.BrH/c1-2-9-20-10-8-15-11-18(21)19(22)12-16(15)17(13-20)14-6-4-3-5-7-14;/h2-7,11-12,17,21-22H,1,8-10,13H2;1H
InChI key   JWQRAXTWDYUBFI-UHFFFAOYSA-N
Gene Information   human ... DRD1(1812)

Description

Application

N-Allyl-(±)-SKF-38393 hydrobromide was used to study dopaminergic signaling in neurons of developing mice and cardiomyocytes injured by oxidants.

Biochem/physiol Actions

N-Allyl-(±)-SKF-38393 hydrobromide is a selective agonist of D1/D5 dopamine receptors. It mimics the physiological action of dopamine and enhances cognition, memory and learning. It decreases the age-related decline in long-term potentiation of mouse hippocampus. SKF-38393 increases the D1-mediated locomotion in rats.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Caution

Light sensitive

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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