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S2321 Sigma-Aldrich

Scyllatoxin

recombinant, expressed in E. coli, ≥95% (HPLC), lyophilized powder

Synonym: LeTx I scorpion toxin, Leiurotoxin I

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Ion Channels, Monovalent Ion Channels, Potassium Channel Modulators,
recombinant   expressed in E. coli
InChI Key   MXWDLLUGULWYIQ-BFRWRHKQSA-N
assay   ≥95% (HPLC)
form   lyophilized powder
shipped in   wet ice
storage temp.   −20°C

Description

Amino Acid Sequence

Ala-Phe-Cys-Asn-Leu-Arg-Met-Cys-Gln-Leu-Ser-Cys-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys-Ile-Gly-Asp-Lys-Cys-Glu-Cys-Val-Lys-His-NH2

Biochem/physiol Actions

Recombinant peptide of scyllatoxin, a 31 amino acid long toxin, originally isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus; selective blocker of apamin-sensitive small-conductance Ca2+-activated K+ channels (SK channels) with highest affinity towards Kca2.2.

Scyllatoxin was used to study small-conductance Ca2+-activated K+ channel signaling in rat superior cervical ganglion neurons. Myometrial strips from non-pregnant women were treated with Scyllatoxin to study the NO-induced relaxation of endometrium.

Reconstitution

Stock solution of 1 μm can be obtained by adding 0.292 mL of any conventional buffer per μg of protein.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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