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S3317 Sigma-Aldrich

SKF-94836

>99% (HPLC), solid

Synonym: N-Cyano-N′-methyl-N″-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]guanidine, Siguazodan

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Properties

assay   >99% (HPLC)
form   solid
color   white
mp   268-268.9 °C (lit.)
solubility   DMSO: freely soluble >5 mg/mL
storage temp.   2-8°C
Gene Information   human ... PDE3A(5139), PDE3B(5140)

Description

Application

Human PBMCs were treated with SKF-94836 to study the role of phosphodiesterases in antigen and mitogen-induced proliferative responses.

Biochem/physiol Actions

SKF-94836 is a potent vasodilator with prolonged effect. It increases the cardiac output and stroke volume and may be useful in treating congestive heart failure. SKF-94836 inhibits the cyclic-AMP hydrolysis by phosphodiesterase in human platelets and exhibits anti-platelet actions.

Phosphodiesterase III (PDE3) inhibitor

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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