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S5321 Sigma-Aldrich

S15535

≥98% (HPLC), solid

Synonym: 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-(2,3-dihydro-1h-inden-2-yl)-piperazine

  • CAS Number 146998-34-7

  • Empirical Formula (Hill Notation) C21H24N2O2

  • Molecular Weight 336.43

  •  MDL number MFCD00911672

  •  PubChem Substance ID 329824452

  •  NACRES NA.77

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Properties

Related Categories Agonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   solid
color   white
solubility   DMSO: ~6 mg/mL
  H2O: insoluble
storage temp.   2-8°C
SMILES string   C1COc2c(O1)cccc2N3CCN(CC3)C4Cc5ccccc5C4
InChI   1S/C21H24N2O2/c1-2-5-17-15-18(14-16(17)4-1)22-8-10-23(11-9-22)19-6-3-7-20-21(19)25-13-12-24-20/h1-7,18H,8-15H2
InChI key   QJPPEMXOOWNICQ-UHFFFAOYSA-N

Description

Application

S15535 may be used in histamine 5-HT1A-medaited cell signaling studies.

Packaging

25 mg in glass bottle

Biochem/physiol Actions

S15535, a benzodioxane, is a selective but partial agonist of histamine 5-HT1A receptor. It activates presynaptic 5-HT1A receptors and suppresses the release of hippocampal 5-HT. It acts as anxiolytic agent and modulates the cholinergic and cognitive function in rodents.3,4

Potent, orally active, partial 5-HT1A receptor agonist

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS09  GHS09
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Serotonin Receptors

Serotonin (5-hydroxytryptamine, 5-HT) is widely distributed throughout the mammalian body, being synthesized from L-tryptophan in enterochromaffin cells of the gastro-intestinal tract as well as in s...
Keywords: Active transport, Atomic absorption spectroscopy, Cancer, Clinical, Gene expression, Ligands, Neurotransmitters, Obesity, Polymorphisms, Schizophrenia, Transduction

Peer-Reviewed Papers
15

References

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