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S5326 Sigma-Aldrich

SB-271046A

≥98% (HPLC)

Synonym: 5-Chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzo-thiophenesulfonamide hydrochloride

  • CAS Number 209481-24-3

  • Empirical Formula (Hill Notation) C20H22ClN3O3S2 · HCl

  • Molecular Weight 488.45

  •  MDL number MFCD10565914

  •  PubChem Substance ID 329824453

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Properties

Related Categories Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
InChI Key   RMXZRJYGJMSDQK-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
solubility   DMSO: >20 mg/mL
originator   GlaxoSmithKline
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

The first potent and selective 5-HT6 antagonist. Training in cognitive tasks, as well as administration SB-271046, induces an increase in pERK1/2 and pCREB1 levels, while CREB2 levels are significantly reduced; cognition-enhancing properties of SB-271046 are attributed to the effect on pERK1/2, not pCREB1/2. SB-271046 reverses MK-801-induced, but not scopolamine-induced, learning impairments. However, with coadministration of galanthamine, both types of learning impairments were ameliorated.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
nwg

Documents

Certificate of Analysis

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