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S6069 Sigma-Aldrich

Sp 5,6-DCl-cBIMPS

≥98% (HPLC), solid

Synonym: 5,6-Dichloro-1-b-D-ribofuranosylbenzimidazole-3′,5′-cyclic monophosphorothioate, Sp- isomer sodium salt

  • CAS Number 120912-54-1

  • Empirical Formula (Hill Notation) C12H10Cl2N2O5PSNa

  • Molecular Weight 419.15

  •  MDL number MFCD06795834

  •  PubChem Substance ID 24724615

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Properties

assay   ≥98% (HPLC)
form   solid
color   white
solubility   H2O: 1 mM
  DMSO: freely soluble
  ethanol: freely soluble
shipped in   dry ice
storage temp.   −70°C

Description

Application

Sp 5,6-DCl-cBIMPS may be used in cAMP-dependent protein kinase-mediated cell signaling studies.

Biochem/physiol Actions

Selective cAMP-dependent protein kinase (PKA) activator. Especially suitable for intact cells showing preference for site B of type II isozyme. Completely stable against mammalian cPDE types I & III and only extremely slowly hydrolized by cPDE type II. Surpasses the widely used but problematic dibutyryl cAMP or 8-CPT-cAMP in terms of metabolic stability, membrane permeability and potency.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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