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  • S6201 - Salinomycin, Ready Made Solution

S6201 Sigma-Aldrich

Salinomycin, Ready Made Solution

from Streptomyces albus, ≥98% (HPLC)

Synonym: Antibiotic 61477, Coxxistac

  • Empirical Formula (Hill Notation) C42H70O11

  • Molecular Weight 751.00

  •  MDL number MFCD25541652

  •  PubChem Substance ID 329824560

  •  NACRES NA.77



Related Categories Antibacterial, Antibiotic Ready Made Solutions, Antibiotics, Antibiotics A to Z, Antibiotics N-S,
Quality Level   200
biological source   Streptomyces albus
assay   ≥98% (HPLC)
concentration   2 mg/ml
solubility   DMSO: soluble
  H2O: insoluble
  alcohols: soluble
  carbon tetrachloride: soluble
  chloroform: soluble
  ethers and esters: soluble
  hexane: soluble
Mode of action   cell membrane | interferes
antibiotic activity spectrum   neoplastics
shipped in   dry ice
storage temp.   −20°C
SMILES string   C[C@@H]1O[C@]([C@]2(C)CC[C@]3([C@H](O)C=C[C@]4(O[C@@]([C@@H](CC)C([C@@H](C)[C@@H](O)[C@H](C)[C@@]5([H])[C@@H](C)CC[C@@]([C@H](C(O)=O)CC)([H])O5)=O)([H])[C@@H](C)C[C@H]4C)O3)O2)([H])CC[C@]1(O)CC
InChI   1S/C42H70O11/c1-11-29(38(46)47)31-15-14-23(4)36(50-31)27(8)34(44)26(7)35(45)30(12-2)37-24(5)22-25(6)41(51-37)19-16-32(43)42(53-41)21-20-39(10,52-42)33-17-18-40(48,13-3)28(9)49-33/h16,19,23-34,36-37,43-44,48H,11-15,17-18,20-22H2,1-10H3,(H,46,47)/t23-,24-,25+,26-,27-,28-,29+,30-,31+,32+,33+,34+,36+,37-,39-,40+,41-,42-/m0/s1


General description

Chemical structure: polyether

Biochem/physiol Actions

Salinomycin is a monocarboxylic polyether antibiotic with unique tricyclic spiroketal ring systems and an unsaturated six-membered ring in the molecule. Salinomycin has antimicrobial and anticoccidial activities. It is an alkali ion carrier with affinity for cations and preference for K+ over other monovalent and divalent cations. Polyether antibiotics (also called carboxylic ionophores) facilitate bidirectional ion flux through the lipid barrier of membranes causing interference with natural ion transport systems both in prokaryotic and eukaryotic cells. Tumor cells express elevated levels of various types of K+ channels, which enhances cell proliferation. Thus, drugs acting as channel blockers inhibit cell proliferation. Being a highly selective potassium ionophore, salinomycin may interfere with potassium channels function in cancer stem cells (CSCs). Established cancer therapies may fail because they kill the bulk tumor cells, but do not eliminate CSCs. Studies indicate that Salinomycin selectively eradicates breast CSCs. Salinomycin may eliminate CSCs by inducing their differentiation. salinomycin suppresses the metastatic migration of 4T1 cells to the lungs.

Physical form

The product is supplied as a 2 mg/mL (2.66 mM) solution in DMSO, 0.2 μm-filtered.

Safety & Documentation

Safety Information

NA 1993 / PGIII
WGK Germany 
Flash Point(F) 
188.6 °F - closed cup
Flash Point(C) 
87 °C - closed cup
Protocols & Articles
Peer-Reviewed Papers


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