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S7201 Sigma-Aldrich

SR-46349 hemifumarate salt

≥98% (HPLC)

Synonym: 4-((3Z)-3-(2-Dimethylaminoethyl)oxyimino-3-(2-fluorophenyl)propen-1-yl)phenol hemifumarate salt, Eplivanserin hemifumarate salt, SR-46349B

  • CAS Number 130580-02-8

  • Empirical Formula (Hill Notation) C19H21FN2O2 · 0.5 C4H4O4

  • Molecular Weight 386.42

  •  MDL number MFCD12546335

  •  PubChem Substance ID 329824579

  •  NACRES NA.77

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Fluorination Ready Pharma-Developed Compounds,
InChI Key   RNLKLYQQDLHHBH-ABDBJYMXSA-N
assay   ≥98% (HPLC)
form   powder
storage condition   protect from light
color   white to off-white
solubility   DMSO: ≥10 mg/mL
originator   Sanofi Aventis
storage temp.   2-8°C

Description

Application

SR-46349 hemifumarate salt may be used in cell signaling studies.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

SR-46349 is an antagonist of 5-HT (2A/2C) receptor and increases the release of dopamine by medial prefrontal cortex in rats.1 It increases the signal transduction induced by 5-HT2 receptor by binding with high affinity.2 SR-46349 inhibits the aggregation of rabbit and human platelets in response to serotonin.3

ASTAR (Antagonist of Serotonin 5HT2A Receptors).

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
2

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Serotonin Receptors

Serotonin (5-hydroxytryptamine, 5-HT) is widely distributed throughout the mammalian body, being synthesized from L-tryptophan in enterochromaffin cells of the gastro-intestinal tract as well as in s...
Keywords: Active transport, Atomic absorption spectroscopy, Cancer, Clinical, Gene expression, Ligands, Neurotransmitters, Obesity, Polymorphisms, Schizophrenia, Transduction

Peer-Reviewed Papers
15

References

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